Health, in its purest sense, is not the primary mission of the nation's K–12 schools, so why should schools feel obligated to address cancer education? The nation's educators are under tremendous pressure to prepare students to pass tests in English language arts and mathematics. As a result, health education and physical education are often assigned third-class status in many of the nation's schools, despite numerous studies supporting the connection between health and academic achievement. Is there a place for cancer prevention education in today's K–12 schools? This commentary explores existing structures that affect cancer prevention education and offers suggestions to improve K–12 health education initiatives.