Abstract
Purpose
To evaluate the clinical changes of adults with cystic fibrosis (CF) during transition
from a pediatric to adult CF center.
Methods
Data were collected at the time of transfer, 1 year earlier and 1 year later, for
all patients in our adult CF center arriving from one of the three pediatric CF centers
in Paris between January 2001 and June 2004.
Results
Sixty-three of the 68 patients (transferred at a median age of 21.0 years) were regularly
attending this adult CF center after 1 year and one had died. The mean number of outpatient
visits increased in the year after transfer (5.7 vs. 3.8 in the year before, p < .001). The occurrence of clinical events and the rate of bronchial colonization
did not change. Pseudomonas aeruginosa was found in about 60% of patients at any time. Pulmonary function declined regularly
with no statistically significant difference in the rate of decline between the 2
years of follow-up (FEV1 was 54.7% predicted at transfer). Nutritional status remained stable (mean body mass
index was 19.1 kg/m2). The number and duration of oral and i.v. antibiotic courses did not change, but
more patients received them at home (p < .001) and self-administered physiotherapy after transfer (p = .001). The proportion of students decreased from 79.3% to 48.1% (p = .02) and the proportion in the workforce increased from 12.7% to 20.4% after transfer.
Conclusions
Patients with CF remained clinically stable during transition and progressively acquired
autonomy.
Keywords
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Article info
Publication history
Published online: June 16, 2008
Accepted:
March 18,
2008
Received:
November 16,
2007
Footnotes
This study was supported by Vaincre la Mucoviscidose.
Identification
Copyright
© 2008 Society for Adolescent Medicine. Published by Elsevier Inc. All rights reserved.
