Journal of Adolescent Health
Volume 44, Issue 4 , Pages 309-315 , April 2009

Reactive Arthritis: A Review

  • Paul S. Kim, M.D.

      Affiliations

    • Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana
    • Corresponding Author InformationAddress correspondence to: Paul S. Kim, M.D., Department of Pediatrics, Indiana University School of Medicine, 410 W 10th Street, Room 1001, Indianapolis, IN 46202.
  • ,
  • Thomas L. Klausmeier, M.D.

      Affiliations

    • Section of Pediatric Rheumatology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Donald P. Orr, M.D.

      Affiliations

    • Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana

Received 23 June 2008 ,Accepted 4 December 2008.

References 

  1. Toivanen A. Bacteria-triggered reactive arthritis: Implications for antibacterial treatment. Drugs. 2001;61:343–351
  2. Hamadulay S, Glynne S, Keat A. When is arthritis reactive?. Postgrad Med J. 2006;82:446–453
  3. Panush R, Wallace D, Dorff R, et al. Retraction of the suggestion to use the term “Reiter's syndrome” sixty-five years later: The legacy of Reiter, a war criminal, should not be eponymic honor but rather condemnation. Arthritis Rheum. 2007;56:693
  4. Leirisalo-Repo M, Sieper J. Reactive arthritis: Epidemiology, clinical features, and treatment. In:  Weisman M,  van der Heijde D,  Reveille J editor. Ankylosing Spondylitis and the Spondyloarthropathies. Philadelphia: Mosby Elsevier; 2006;p. 53–64
  5. Orchard T, Jewell D. Articular and ocular complications of inflammatory bowel disease. In:  Targan S,  Shanahan F,  Karp L editor. Inflammatory Bowel Disease: From Bench to Bedside. 2nd Edition. Dordrecht: Kluwer: Academic Publishers; 2003;p. 747–756
  6. Palm O, Moum B, Jahnsen J, et al. The prevalence and incidence of peripheral arthritis in patients with inflammatory bowel disease, a prospective population-based study. Rheumatology. 2001;40:1256–1261
  7. Passo M, Fitzgerald J, Brandt K. Arthritis associated with inflammatory bowel disease in children. Relationship of joint disease to activity and severity of bowel lesion. Dig Dis Sci. 1986;31:492–497
  8. Petty R, Southwood T, Manners P, et al. International League of Associations for Rheumatology Classification of Juvenlie Idiopathic Arthritis: Second Revision, Edmonton, 2001. J Rheumatol. 2004;31:390–392
  9. Bas S, Scieux C, Vischer T. Male sex predominance in Chlamydia trachomatis sexually acquired reactive arthritis: Are women more protected by anti-chlamydia antibodies?. Ann Rheum Dis. 2001;60:605–611
  10. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. 2007;369:767–778
  11. Hannu T, Mattila L, Siitonen A, et al. Reactive arthritis attributable to Shigella infection: A clinical and epidemiological nationwide study. Ann Rheum Dis. 2005;64:594–598
  12. Dworkin M, Shoemaker P, Goldoft M, et al. Reactive arthritis and Reiter's syndrome following an outbreak of gastroenteritis caused by Salmonella enteritidis. Clinical Infectious Diseases. 2001;33:1010–1014
  13. Rich E, Hook E, Alarcon G, et al. Reactive arthritis in patients attending an urban sexually transmitted diseases clinic. Arthritis Rheum. 1996;39:1172–1177
  14. Singh R, Shasany K, Aggarwal A, et al. Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. Clin Exp Immunol. 2007;148:486–493
  15. Hughes R, Keat A. Reiter's syndrome and reactive arthritis: A current view. Seminars in Arthritis and Rheumatism. 1994;24:190–210
  16. Pacheco-Tena C, Alvarado de la Barrera C, Lopez-Vidal Y, et al. Bacterial DNA in synovial fluid cells of patients with juvenile onset spondyloarthropathies. Rheumatology. 2001;40:920–927
  17. Ekman P, Kirveskari J, Granfors K. Modification of disease outcome in Salmonella-infected patients by HLA-B27. Arthritis Rheum. 2000;43:1527–1534
  18. Leirisalo-Repo M, Helenius P, Hannu T, et al. Long term prognosis of reactive salmonella arthritis. Ann Rheum Dis. 1997;56:516–520
  19. Bas S, Kvien T, Buchs N, et al. Lower level of synovial fluid interferon-γ in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. Rheumatology. 2003;42:461–467
  20. Yin Z, Braun J, Neure L, et al. Crucial role of interleukin-10 / interleukin-12 balance in the regulation of the type 2 T-helper cytokine response in reactive arthritis. Arthritis Rheum. 1997;40:1788–1797
  21. Braun J, Kingsley G, van der Heijde D, et al. On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th international workshop on reactive arthritis, Berlin, Germany, July 3–6, 1999. J Rheumatol 2000;27:2185–92.
  22. Hannu T, Mattila L, Rautelin H, et al. Campylobacter-triggered reactive arthritis: A population-based study. Rheumatology. 2002;41:312–318
  23. Novaro G, Erim T, Pinski S. Spondyloarthropathy-associated aortitis and massive thickening of the aortic-mitral curtain: Diagnosis by echocardiography. Cardiology. 2006;106:98–101
  24. Vassilopoulos D, Calabrese L. Virally associated arthritis 2008: Clinical, epidemiologic, and pathophysiologic considerations. Arthritis Res Ther. 2008;10:215–222
  25. O'Brien J, Goldenberg D, Rice P. Disseminated gonococcal infection: A prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms. Medicine. 1983;62:395–406
  26. Sieper J, Rudwaleit M, Braun J, et al. Diagnosing reactive arthritis: Role of clinical setting in the value of serologic and microbiologic assays. Arthritis Rheum. 2002;46:319–327
  27. Fendler C, Laitko S, Sorensen H, et al. Frequency of triggering bacteria in patients with reactive arthritis and undifferentiated oligoarthritis and the relative importance of the tests used for diagnosis. Ann Rheum Dis. 2001;60:337–343
  28. Kobayashi S, Kida I. Reactive arthritis: Recent advances and clinical manifestations. Internal Medicine. 2005;44:408–412
  29. Clegg D, Reda D, Weisman M, et al. Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome): A Department of Veterans Affairs cooperative study. Arthritis Rheum. 1996;39:2021–2027
  30. Flagg S, Meador R, Hsia E, et al. Decreased pain and synovial inflammation after etanercept therapy in patients with reactive and undifferentiated arthritis: An open-label trial. Arthritis Rheum. 2005;53:613–617
  31. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2006. MMWR. 2006;55:38–42
  32. Panayi G, Clark B. Minocycline in the treatment of patients with Reiter's syndrome. Clin Exp Rheumatol. 1989;7:100–101
  33. Lauhio A, Leirisalo-Repo M, Lahdevirta J, et al. Double-blind, placebo-controlled study of three-month treatment with lymecycline in reactive arthritis, with special reference to Chlamydia arthritis. Arthritis Rheum. 1991;34:6–14
  34. Yli-Kerttula T, Luukkainen R, Yli-Kerttula U, et al. Effect of three month course of ciprofloxacin on the outcome of reactive arthritis. Ann Rheum Dis. 2000;59:565–570
  35. Kvien T, Gaston J, Bardin T, et al. Three month treatment of reactive arthritis with azithromycin: A EULAR double blind, placebo controlled study. Ann Rheum Dis. 2004;63:1113–1119
  36. Smieja M, MacPherson D, Kean W, et al. Randomised, blinded, placebo controlled trial of doxycycline for chronic seronegative arthritis. Ann Rheum Dis. 2001;60:1088–1094
  37. Leirisalo-Repo M. Prognosis, course of disease, and treatment of the spondylarthropaties. Rheum Dis Clin North Am. 1998;24:737–751

PII: S1054-139X(08)00654-X

doi: 10.1016/j.jadohealth.2008.12.007

Journal of Adolescent Health
Volume 44, Issue 4 , Pages 309-315 , April 2009