Journal of Adolescent Health
Volume 43, Issue 1 , Pages 8-14 , July 2008

Adolescent and Adult Participation in an HIV Vaccine Trial Preparedness Cohort in South Africa

  • Keren Middelkoop, M.B.ChB.

      Affiliations

    • Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa
    • Corresponding Author InformationAddress correspondence to: Keren Middelkoop, M.B.ChB., Desmond Tutu HIV Centre, P.O. Box 13801, Mowbray, Cape Town, South Africa 7705.
    • ,
  • Landon Myer, M.A., M.Phil., Ph.D.

      Affiliations

    • Infectious Diseases Epidemiology Unit, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa
    • Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York
    • ,
  • Daniella Mark, B.Soc.Sc. (Hons), M.Soc.Sc.

      Affiliations

    • Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa
    • ,
  • Sibonisile P. Mthimunye

      Affiliations

    • Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa
    • ,
  • Joalida Smit, B.A. (Hons), M.A.

      Affiliations

    • Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa
    • ,
  • Robin Wood, B.M., B.Ch., F.C.P., M.Med.

      Affiliations

    • Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa
    • ,
  • Linda-Gail Bekker, M.B.Ch.B., F.C.P., Ph.D.

      Affiliations

    • Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa
    • Department of Medicine, University of Cape Town, Cape Town, South Africa

Received 19 June 2007 ,Accepted 16 November 2007.

References 

  1. UNAIDS 2004 Report on the global AIDS epidemic. Focus: HIV and young people: the threat for today's youth. http://www.unaids.org/bangkok2004/GAR2004_pdf/Focus_youth_en.pdf
  2. World Health Organisation. Child and Adolescent Health and Development. http://www.who.int/child-adolescent-health/HIV/HIV_adolescents.htm
  3. Report: National HIV and Syphilis Antenatal Sero-Prevalence Survey in South Africa 2005, Department of Health, Republic of South Africa. www.doh.gov.za/docs/reports/2005/hiv.pdf
  4. McClure CA, Gray G, Rybczyk GK, et al. Challenges to conducting HIV preventative vaccine trials with adolescents. J Acquir Immune Defic Syndr. 2004;36:726–733
  5. Jaspan HB, Gray GE, Robinson AK, et al. Scientific justification for the participation of children and adolescents in IV-1 vaccine trials in South Africa. S Afr Med J. 2005;95:685–687
  6. Slack C, Strode A, Grant C, et al. Implications of the ethical-legal framework for adolescent HIV vaccine trials—report of a consultative forum. S Afr Med J. 2005;95:682–684
  7. Van Wyk C. The participation of minors in preventative HIV research trials in South Africa: legal and human rights considerations. Med Law. 2003;22:589–598
  8. Bekker LG, Jaspan H, McIntyre J, et al. Adolescents and HIV vaccine trials: what are the clinical trials site issues?. J Int Assoc Physicians AIDS Care. 2005;4:93–97
  9. Swartz L, Kagee Z, Smit J, et al. Social and behavioural aspects of child and adolescent participation in HIV vaccine trials. J Int Assoc Physicians AIDS Care. 2005;4:89–92
  10. Stanford PD, Monte DA, Briggs FM, et al. Recruitment and retention of adolescent participants in HIV research: findings from the REACH (Reaching for Excellence in Adolescent Care and Health) Project. J Adolesc Health. 2003;32:192–203
  11. De Souza CTV, Lowndes CM, Szwarcwald CL, et al. Willingness to participate in HIV vaccine trials among a sample of men who have sex with men, with and without a history of commercial sex, Rio de Janiero, Brazil. AIDS Care. 2003;15:539–548
  12. Bartholow BN, MacQueen KM, Douglas JM, et al. Assessment of the changing willingness to participate in phase III HIV vaccine trials among men who have sex with men. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16:108–115
  13. Murphy DA, Hoffman D, Seage GR, et al. Improving comprehension for HIV vaccine trial information among adolescents at risk of HIV. AIDS Care. 2007;19:42–51
  14. Sahay S, Mehendale S, Sane S, et al. Correlates of HIV vaccine trial participation: an Indian perspective. Vaccine. 2005;23:1351–1358
  15. Kiwanuka N, Kigozi G, Birx D, et al. Knowledge about vaccines and willingness to participate in preventative HIV vaccine trials: a population-based study, Rakai, Uganda. J Acquir Immune Defic Syndr. 2004;36:721–725
  16. Jaspan HB, Berwick JR, Myer L, et al. Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials. J Adolesc Health. 2006;39:642-28
  17. Wood R, Middelkoop K, Myer L, et al. The burden of undiagnosed pulmonary tuberculosis (TB) in an African community with high HIV-prevalence: implications for TB control. Am J Respir Crit Care Med. 2007;175:87–93
  18. Jenkins RA, Suchada C, Morgan PA, et al. Motivation, recruitment and screening of volunteers for a Phase I/II HIV preventive vaccine trial in Thailand. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;18:171–177
  19. Dixon DO, Rida WN, Fast PE, et al. HIV vaccine trials: some design issues including sample size calculations. J Acquir Immune Defic Syndr. 1993;6:485–496
  20. Heyward WL, Osmanov S, Saba J, et al. Preparation for phase III HIV vaccine efficacy trials: methods for the determination of HIV incidence. AIDS. 1994;8:1285–1291

PII: S1054-139X(07)00645-3

doi: 10.1016/j.jadohealth.2007.11.144

Journal of Adolescent Health
Volume 43, Issue 1 , Pages 8-14 , July 2008

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