Journal of Adolescent Health
Volume 37, Issue 6 , Pages 517.e1-517.e5 , December 2005

Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine in healthy Taiwanese children and adolescents

  • Li-Min Huang, MD, PhD

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Luan-Yin Chang, MD, PhD

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Haiwen Tang, MD, PhD

      Affiliations

    • GlaxoSmithKline Biologicals, Rixensart, Belgium
    • ,
  • Hans L. Bock, MD

      Affiliations

    • GlaxoSmithKline Biologicals, Rixensart, Belgium
    • ,
  • Chun-Yi Lu, MD

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Fu-Yuan Huang, MD

      Affiliations

    • Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Tzou-Yien Lin, MD

      Affiliations

    • Chang Gung Children’s Hospital and Chang Gung University, College of Medicine, Taoyuan, Taiwan
    • Corresponding Author InformationAddress correspondence to: Dr. Tzou-Yien Lin, Chang Gung Children’s Hospital, No. 5, Fu-shin St, Kweishang, Taipei, Taiwan.
    • ,
  • Chin-Yun Lee, MD

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan

Received 3 May 2005 ,Accepted 10 August 2005.

References 

  1. Davey S . The vaccine challenge . In: State of the World’s Vaccines and Immunisation . Geneva: World Health Organization and United Nations Children’s Fund; 1996;p. 1–25
  2. Giammanco A , Chiarini A , Stroffolini T , et al.   Seroepidemiology of pertussis in Italy . Rev Infect Dis . 1991;13:1216–1220
  3. Black S . Epidemiology of pertussis . Pediatr Infect Dis J . 1997;16(suppl):85–89
  4. Baron S , Njamkepo E , Grimprel E , et al.   Epidemiology of pertussis in French hospitals in 1993 and 1994 (thirty years after a routine use of vaccination) . Pediatr Infect Dis J . 1998;17:412–418
  5. Centers for Disease Control and Prevention . Pertussis outbreaks—Massachusetts and Maryland, 1992 . MMWR . 1993;147:522–525
  6. Cromer BA , Goydos J , Hackell J , et al.   Unrecognized pertussis infection in adolescents . Am J Dis Child . 1993;147:575–577
  7. He Q , Viljanen MK , Nikkari S , et al.   Outcomes of Bordetella pertussis infection in different age groups of an immunised population . J Infect Dis . 1994;17:873–877
  8. Keitel WA , Edwards KM . Pertussis in adolescents and adults (time to reimmunize?) . Semin Respir Infect . 1995;10:51–57
  9. Nennig ME , Shinefield HR , Edwards KM , et al.   Prevalence and incidence of adult pertussis in an urban population . JAMA . 1996;275:1672–1674
  10. Robertson PW , Goldberg H , Jarvie BH , et al.   Bordetella pertussis infection (a cause of persistent cough in adults) . Med J Aust . 1987;147:522–525
  11. Bass JW , Wittler RR . Return of epidemic pertussis in the United States . Pediatr Infect Dis J . 1994;13:343–345
  12. Cherry JD , Baraff LJ , Hewlett E . The past, present and future of pertussis. The role of adults in epidemiology and future control . West J Med . 1989;150:319–328
  13. Hoppe JE . Update on epidemiology, diagnosis, and treatment of pertussis . Eur J Clin Microbiol Infect Dis . 1996;15:189–193
  14. Mortimer EA . Pertussis and its prevention (a family affair) . J Infect Dis . 1990;161:473–479
  15. Nelson JD . The changing epidemiology of pertussis in young infants (the role of adults as reservoirs of infection) . Am J Dis Child . 1978;132:371–373
  16. Mertsola J , Ruuskanen O , Eerola E , Viljanen MK . Intrafamilial spread of pertussis . J Pediatr . 1983;103:359–363
  17. Long SS , Welkon CJ , Clark JL . Widespread silent transmission of pertussis in families (antibody correlates of infection and symptomatology) . J Infect Dis . 1990;161:480–486
  18. Izurieta HS , Kenyon TA , Strebel PM , et al.   Risk factors for pertussis in young infants during an outbreak in Chicago in 1993 . Clin Infect Dis . 1996;22:503–507
  19. Fine PE . Adult pertussis (a salesman’s dream—and an epidemiologist’s nightmare) . Biologicals . 1997;25:195–198
  20. Deville JG , Cherry JD , Christenson PD , et al.   Frequency of unrecognized Bordetella pertussis infections in adults . Clin Infect Dis . 1995;21:639–642
  21. National Advisory Committee on Immunisation, the Advisory Committee on Epidemiology, the Canadian Paediatric Society . Statement on management of persons exposed to pertussis and pertussis outbreak control . Can Med Assoc J . 1995;152:712–716
  22. Immunization Practices Advisory Committee . Diphtheria, tetanus and pertussis (recommendations for vaccine use and other preventive measures) . MMWR Recomm Rep . 1991;40:1–28
  23. Decker MD , Edwards KM , Steinhoff MC , et al.   Comparison of 13 acellular pertussis vaccines (adverse reactions) . Pediatrics . 1995;96:557–566
  24. Pichichero ME . Acellular pertussis vaccines. Towards an improved safety profile . Drug Saf . 1996;15:311–324
  25. Kimura M , Kuno-Sakai H , Sato Y , et al.   A comparative trial of the reactogenicity and immunogenicity of Takeda acellular pertussis vaccine combined with tetanus and diphtheria toxoids. Outcome in 3- to 8-month-old infants, 9- to 23-month-old infants and children, and 24- to 30-month-old children . Am J Dis Child . 1991;145:734–741
  26. Edwards KM , Decker MD , Graham BS , et al.   Adult immunization with acellular pertussis vaccine . JAMA . 1993;269:53–56
  27. Liese JG , Stojanov S , Belohradsky BH . Pertussis vaccination with acellular vaccines. Tolerance—effectiveness—current vaccination recommendations . Fortschr Med . 1997;115:22–27
  28. Anderson RM , May RM . Immunization and herd immunity . Lancet . 1990;335:641–645
  29. Hadler SC . Cost benefit of combining antigens . Biologicals . 1994;22:415–418
  30. Begue P , Grimprel E . Future combined vaccines . J Infect Dis . 1996;174(suppl 3):S295–S297
  31. Van der Wielen M , Van Damme P , Joossens E , et al.   A randomized controlled trial with a diphtheria-tetanus-acellular pertussis (dTpa) vaccine in adults . Vaccine . 2000;18(20):2075–2082
  32. Ruuskanen O , Noel A , Putto-Laurila A , et al.   Development of an acellular pertussis vaccine and its administration as a booster in healthy adults . Vaccine . 1991;9:117–121
  33. Annunziato PW , Rothstein EP , Bernstein HH , et al.   Comparison of a three-component acellular pertussis vaccine with a whole-cell pertussis vaccine in 4- through 6-year-old children . Arch Pediatr Adolescent Med . 1994;148(5):503–507
  34. Bernstein HH , Rothstein EP , Reisinger KS , et al.   Comparison of a three-component acellular pertussis vaccine with a whole-cell pertussis vaccine in 15- through 20-month-old infants . Pediatrics . 1994;93:656–659
  35. Kanra G , Ceyhan M , Vandevoorde D , Bogaerts H . Acellular pertussis diphtheria-tetanus-pertussis vaccine containing separately purified pertussis toxoid, filamentous hemagglutinin and 69 kDa outer membrane protein as a booster in children . Eur J Pediatr . 1993;152:478–483
  36. Englund JA , Decker MD , Edwards KM , et al.   Acellular and whole-cell pertussis vaccines as a booster dose (a multicentre study) . Pediatrics . 1994;93:37–43
  37. Pichichero ME , Deloria MA , Rennels MB , et al.   A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fourth dose in 15- to 20-month-old children . Pediatrics . 1997;100:772–788
  38. Schmitt H-J , Beutel K , Schuind A , et al.   Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age . J Pediatr . 1997;130:616–623
  39. Zepp F . Reactogenicity of booster doses (field experiences in Germany) . Proceedings of the Acellular Pertussis Vaccine Conference . 2000; Bethesda, MD:
  40. Dagan R , Igbaria K , Piglansky L , et al.   Reactogenicity and immunogenicity of reduced antigen content diphtheria-tetanus-acellular pertussis vaccines as a booster in 4–7-year-old children primed with diphtheria-tetanus-whole cell pertussis vaccine before 2 years of age . Vaccine . 1999;17(20–21):2620–2627
  41. Minh NNT , He Q , Ramalho A , et al.   Acellular vaccines containing reduced quantities of pertussis antigens as a booster in adolescents . Pediatrics . 1999;104(6):1377–1378

PII: S1054-139X(05)00392-7

doi: 10.1016/j.jadohealth.2005.08.009

Journal of Adolescent Health
Volume 37, Issue 6 , Pages 517.e1-517.e5 , December 2005

Article Tools