Journal of Adolescent Health
Volume 32, Issue 1 , Pages 94-97 , January 2003

The unusual association of three autoimmune diseases in a patient with Noonan syndrome

  • Antonio Amoroso, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Pierluigi Garzia, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Marta Vadacca, M.D.

      Affiliations

    • University Campus Bio-medico, Rome, Italy (M.V., A. Afeltra)
    • ,
  • Sara Galluzzo, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Flavia Del Porto, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Anna P Mitterhofer, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Antonella Afeltra, M.D.

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to: Antonio Amoroso, M.D., Department of Clinical Medicine, Policlinico Umberto I, Viale del Policlinico 00161, Rome, Italy
    • University Campus Bio-medico, Rome, Italy (M.V., A. Afeltra)

,Accepted 23 January 2002.

References 

  1. Noonan JA, Ehmke DA. Associated non-cardiac malformations in children with congenital heart disease. J Pediatr. 1963;63:468–470
  2. Noonan JA. Noonan syndrome (An update and review for the primary pediatrician). Clin Pediatr. 1994;9:548–555
  3. Jamieson CR, van der Burgt I, Brady AF, et al.  Mapping a gene for Noonan syndrome to the long arm of chromosome 12. Nat Genet. 1994;4:357–360
  4. Flick JT, Singh AK, Kizer J, Lazarchick J. Platelet dysfunction in Noonan’s syndrome. Am J Clin Pathol. 1991;95:739–742
  5. Vesterhus P, Aarskog D. Noonan’s syndrome and autoimmune thyroiditis. J Pediatr. 1973;83:237–240
  6. Chaves-Carballo E, Hayles AB. Ullrich-Turner syndrome in the male (Review of the literature and report of a case with lymphocytic (Hashimoto’s) thyroiditis). Mayo Clin Proc. 1966;41:483–487
  7. Ortega Barba MG, Reyes PA, Herrera EL, Barrios R. Classical interstitial pneumonitis and mixed cryoglobulinemia in a male with Turner phenotype (Report of a case and review of the literature). Arch Inst Cardiol Mex. 1979;49:114–124
  8. Saito Y, Sasaki M, Hanaoka S, et al.  A case of Noonan syndrome with cortical dysplasia. Pediatr Neurol. 1997;17:266–269
  9. Robertson S, Tsang B, Aftimos S. Cerebral infarction in Noonan syndrome. Am J Med Genet. 1997;71:111–114
  10. Mihailova D, Grigorova R, Vassileva B, et al.  Autoimmune thyroid disorders in juvenile chronic arthritis and systemic lupus erythematosus. Adv Exp Med Biol. 1999;455:55–60
  11. Romano C, Bartolone S, Sferlazzas C, et al.  Systemic lupus erythematosus and celiac disease. Clin Exp Rheumatol. 1997;15:582–583
  12. Caramaschi P, Riccetti MM  Fratta , Pasini A, et al.  Systemic lupus erythematosus and thrombotic thrombocytopenic purpura (Report of three cases and review of the literature). Lupus. 1998;7:37–41
  13. Sharland M, Patton MA, Talbot S, et al.  Coagulation-factor deficiencies and abnormal bleeding in Noonan’s syndrome. Lancet. 1992;339:19–21
  14. Singer ST, Hurst D, Addiego J. Bleeding disorders in Noonan syndrome (Three reports and review of the literature). J Pediatr Hematol Oncol. 1997;19:130–134
  15. Noonan JA. Hypertelorism with Turner phenotype (A new syndrome with associated congenital heart disease). Am J Dis Child. 1968;116:373–380
  16. Collins E, Turner G. The Noonan syndrome (A review of the clinical and genetic features of 27 cases). J Pediatr. 1973;83:941–950

PII: S1054-139X(02)00364-6

Journal of Adolescent Health
Volume 32, Issue 1 , Pages 94-97 , January 2003

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