Journal of Adolescent Health
Volume 32, Issue 1 , Pages 94-97, January 2003

The unusual association of three autoimmune diseases in a patient with Noonan syndrome

  • Antonio Amoroso, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Pierluigi Garzia, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Marta Vadacca, M.D.

      Affiliations

    • University Campus Bio-medico, Rome, Italy (M.V., A. Afeltra)
    • ,
  • Sara Galluzzo, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Flavia Del Porto, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Anna P Mitterhofer, M.D.

      Affiliations

    • Department of Clinical Medicine, University of Rome “La Sapienza,” Rome, Italy (A. Amoroso, P.G., S.G., F.D.P.)
    • ,
  • Antonella Afeltra, M.D.

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to: Antonio Amoroso, M.D., Department of Clinical Medicine, Policlinico Umberto I, Viale del Policlinico 00161, Rome, Italy
    • University Campus Bio-medico, Rome, Italy (M.V., A. Afeltra)

Accepted 23 January 2002.

Abstract 

Abstract

We report on a 26-year-old female affected by Noonan syndrome (NS), a congenital disorder characterized by various phenotypic features and congenital anomalies) associated with a variety of autoimmune diseases, including systemic lupus erythematosus, celiac disease, and Hashimoto thyroiditis. Autoimmunity is seldom described in NS and the association between this congenital disease and three autoimmune disorders has not been previously reported. Should the occurrence of autoimmune disorders in NS be confirmed, a relevant clinical and laboratory evaluation of NS patients should be performed in order to clarify whether the immune system involvement represents only an occasional event or is a feature of the disease.

Keywords:  Adolescent autoimmunity, Noonan syndrome, Systemic lupus erythematosus, Celiac disease, Hashimoto thyroiditis

 

PII: S1054-139X(02)00364-6

Journal of Adolescent Health
Volume 32, Issue 1 , Pages 94-97, January 2003

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