Journal of Adolescent Health
Volume 31, Issue 4 , Pages 378-380 , October 2002

Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia

  • TÜL.A.Y. ERKAN, M.D.

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Tülay Erkan, M.D., Vişnezade mah. Kireçhane sok. Türker apt. no:9/4, Beşiktaş 80 690 Istanbul, Turkey
    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey
    • ,
  • Ç.I.G.D.E.M. AKTUGLU, M.D.

      Affiliations

    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey
    • ,
  • E.M.A.H.I.R. GÜLCAN, M.D.

      Affiliations

    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey
    • ,
  • T.U.F.A.N. KUTLU, M.D.

      Affiliations

    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey
    • ,
  • FÜG.E.N. ÇULLU, M.D.

      Affiliations

    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey
    • ,
  • H.I.L.M.I. APAK, M.D.

      Affiliations

    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey
    • ,
  • GÜNGÖR.T. TÜMAY, M.D.

      Affiliations

    • Department of Pediatrics (Ç.A.), Division of Gastroenterology (T.E., E.M.G., T.K. F.Ç., G.T.T.) and Division of Hematology-Oncology (H.A.), Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey

,Accepted 13 December 2001.

References 

  1. Sokol RJ, Narkewicz MR. Copper and iron storage disorders. In:  Suchy FJ,  Sokol RJ,  Balistreri WF editor. Liver Disease in Children. 2nd Ed. iton. Philadelphia: Lippincott Williams & Wilkins; 2001;p. 595–640
  2. Schwarzenberg SJ, Sharp HL. Update on metabolic liver disease. Pediatr Clin North Am. 1996;43:28–32
  3. Gitlin N. Wilson disease (the scourge of copper). J Hepatol. 1998;28:734–739
  4. Baban NK, Hubbs DT, Roy TM. Wilson’s disease. South Med J. 1997;90:535–538
  5. Chu NS, Hung TP. Geographic variations in Wilson’s disease. J Neurol Sci. 1993;117:1–7
  6. Chu KK, Chen CL. Abatement of secondary amenorrhea in Wilson’s disease following liver transplantation. Transplant Proc. 1992;24:1468–1469
  7. Kaushansky A, Frydman M, Kaufman H, Homburg R. Endocrine studies of the ovulatory disturbances in Wilson’s disease. Fertil Steril. 1987;47:270–273
  8. Hartemann P, Leclere J, Thomas JL, Genton P. Gonadotropin-resistant ovary syndrome and Wilson’s disease. A case. Rev Med İnterne. 1983;4:353–355
  9. Donfrid M, Jankovic G, Strahinja R, et al.  Idopathic thrombocytopenia associated with Wilson’s disease. Hepatogastroenterology. 1998;45:1774–1776
  10. Owen CA, Goldstein NP, Bowie JW. Platelet function and coagulation in patients with Wilson disease. Arch Intern Med. 1976;136:148–152
  11. Hoagland HC, Goldstein NP. Hematologic (cytopenic) manifestations of Wilson’s disease (hepatolenticular degeneration). Mayo Clin Proc. 1978;53:498–500
  12. Kawasaki T, Takeshita A, Souda K, et al.  Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis. Am J Gastroenterol. 1999;94:1918–1922
  13. Yamashita K, Matsuoka H, Ochiai T, et al.  Hepatocyte growth factor/scatter factor enhances the thrombopoietin mRNA expression in rat hepatocytes and cirrhotic rat livers. J Gastroenterol Hepatol. 2000;15:83–90
  14. Rahimi N, Etchells S, Elliott B. Hepatocyte growth factor (HGF) is a copper-binding protein (In a facile probe for purification of HGF by immobilized CU(II)-affinity chromatography). Protein Expr Purif. 1996;7:329–333
  15. Cundy TF, Butler J, Pope RM, et al.  Amenorrhea in women with non-alcoholic chronic liver disease. Gut. 1991;32:202–206
  16. Louvet JP, Harman SM, Schreiber JM, Ross GT. Evidence of a role of androgen in follicular maturation. Endocrinology 1975;97:366–72.

PII: S1054-139X(02)00355-5

Journal of Adolescent Health
Volume 31, Issue 4 , Pages 378-380 , October 2002

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