Journal of Adolescent Health
Volume 30, Issue 4, Supplement 1 , Pages 49-58 , April 2002

Puberty and the emergence of gender differences in psychopathology

  • Chris Hayward, M.D. (M.P.H.)

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Chris Hayward, M.D., M.P.H., Stanford University, 401 Quarry Road, #1316, Stanford, CA 94305 USA
    • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
  • ,
  • Katherine Sanborn, M.D.

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA

,Accepted 19 April 2001.

References 

  1. Hayward C (ed). Gender Differences at Puberty. Cambridge, MA: Cambridge University Press. (In press)
  2. Hayward C, Killen JD, Hammer L, Litt IF. Pubertal stage and panic attack history in sixth- and seventh-grade girls. Am J Psychiatry. 1992;149:1239–1243
  3. Killen JC, Hayward C, Litt IF, et al.  Is puberty a risk factor for eating disorders?. Am J Dis Child. 1992;146:323–325
  4. Angold A, Costello EJ, Worthman CM. Puberty and depression (The roles of age, pubertal status and pubertal timing). Psychol Med. 1998;28:51–61
  5. Patton GC, Hibbert ME, Carlin J, et al.  Menarche and the onset of depression and anxiety in Victoria, Australia. J Epidemiol Community Health. 1996;50:661–666
  6. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Childhood. 1970;45:13–23
  7. Alsaker FD. Pubertal timing, overweight, and psychological adjustment. J Early Adolescence. 1992;12:396–419
  8. Blyth DA, Simmons RG, Zakin DF. Satisfaction with body image for early adolescent females (The impact of pubertal timing within different school environments. Special Issue: Time of maturation and psychosocial functioning in adolescence). J Youth Adolesc. 1985;14:207–225
  9. Brooks-Gunn J, Petersen AC, Eichorn D. The study of maturational timing effects in adolescence.Special Issue (Time of maturation and psychosocial functioning in adolescence). J Youth Adolesc. 1985;14:149–161
  10. Brooks-Gunn J, Warren MP. Biological and social contributions to negative affect in young adolescent girls. Child Dev. 1989;60:40–55
  11. Duncan PD, Ritter PL, Dornbusch SM, et al.  The effects of pubertal timing on body image, school behavior, and deviance. Special Issue (Time of maturation and psychosocial functioning in adolescence). J Youth Adolesc. 1985;14:227–235
  12. Petersen AC, Crockett L. Pubertal timing and grade effects on adjustment. Special Issue (Time of maturation and psychosocial functioning in adolescence). J Youth Adolesc. 1985;14:191–206
  13. Simmons RG, Blyth DA, Mckinney KS. The social and psychological effects of puberty on white females. In:  Brooks-Gunn J,  Petersen A editor. Girls at Puberty (Biological and Psychosocial Perspectives). New York: Plenum; 1983;p. 229–272
  14. Tobin-Richards MH, Boxer AM, Peterson AV. The psychological significance of pubertal change (Sex differences in perceptions of self during early adolescence). In:  Brooks-Gunn J,  Petersen A editor. Girls at Puberty (Biological and Psychosocial Perspectives). New York: Plenum; 1983;p. 127–154
  15. Simmons RG, Blyth DA. Moving into Adolescence (The Impact of Pubertal Change and School Context). Hawthorne, NY: Aldine De Gruyter; 1987;
  16. Magnusson D, Stattin H, Allen VL. Biological maturation and social development (A longitudinal study of some adjustment processes from mid-adolescence to adulthood. Special Issue: Time of maturation and psychosocial functioning in adolescence). J Youth Adolesc. 1985;14:267–283
  17. Hayward C, Killen JD, Wilson DM, Hammer LD. Psychiatric risk associated with early puberty in adolescent girls. J Am Acad Child Adolesc Psychiatry. 1997;36:255–262
  18. Graber JA, Lewinsohn PM, Seeley JR, Brooks-Gunn J. Is psychopathology associated with the timing of pubertal development?. J Am Acad Child Adolesc Psychiatry. 1997;36:1768–1776
  19. Silbereisen RK, Kracke B. Variation in maturational timing and adjustment in adolescence. In:  Jackson S,  Rodriguez-Tome H editor. The Social Worlds of Adolescence. East Sussex, NJ: Erlbaum; 1993;p. 67–94
  20. Angold A, Costell EJ, Erkanli A, et al.  Pubertal changes in hormone levels and depression in girls. Psychol Med. 1999;29:1043–1053
  21. Paikoff RL, Brooks-Gunn J, Warren MP. Effects of girls hormonal status on depressive and aggressive symptoms over the course of one year. Special Issue (The emergence of depressive symptoms during adolescence). J Youth Adolesc. 1991;20:191–215
  22. Susman EJ, Dorn LD, Chrousos GP. Negative affect and hormone levels in young adolescents (Concurrent and predictive perspectives. Special Issue: The emergence of depressive symptoms during adolescence). J Youth Adolesc. 1991;20:167–190
  23. Nottleman ED, Susman EJ, Dorn LD, et al.  Developmental processes in early adolescence (Relationships between adolescent adjustment problems and chronological age, pubertal stage, and puberty-related serum hormone levels). J Pediatr. 1987;110:473–480
  24. Slap GB, Khalid N, Paikoff RL, et al.  Evolving self-image, age, pubertal manifestations, and pubertal hormones (Preliminary findings in young adolescent girls). J Adolesc Health. 1994;15:327–335
  25. Goodyer IM, Herbert J, Tamplin A, et al.  Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents. Br J Psychiatry. 2000;177:499–504
  26. Goodyer IM, Herbert J, Tamplin A. First-episode major depression in adolescents. Affective, cognitive and endocrine characteristics of risk status and predictors of onset. Br J Psychiatry. 2000;176:142–149
  27. Susman EJ, Nottelmann ED, Inoff-Germain G. Hormonal influences on aspects of psychological development during adolescence. J Adolesc Health Care. 1987;8:492–504
  28. Susman EJ, Inoff-Germain G, Nottelmann ED. Hormones emotional dispositions, and aggressive attributes in young adolescents. Child Dev. 1987;58:1114–1134
  29. Rubinow DR, Schmidt PJ. Androgens, brain, and behavior. Am J Psychiatry. 1996;153:974–984
  30. Simerly RB, Chang C, Muramatsu M, Swanson LW. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain (An in situ hybridization study). J Comp Neurol. 1990;294:76–95
  31. Halbreich U, Lumley LA. The multiple interactional biological processes that might lead to depression and gender differences in its appearance. J Affect Disord. 1993;29:159–173
  32. Lambert JJ, Belelli D, Hill-Venning C, et al.  Neurosteroid modulation of native and recombinant GABAA receptors. Cell Mol Neurobiol. 1996;16:155–174
  33. Attali G, Weizman A, Gil-Ad I, Rehavi M. Opposite modulatory effects of ovarian hormones on rat brain dopamine and serotonin transporters. Brain Res. 1997;756:153–159
  34. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL. Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. J Neurosci. 1996;16:7021–7029
  35. Seeman MV. Psychopathology in women and men (Focus on female hormones). Am J Psychiatry. 1997;154:1641–1647
  36. Giedd JN, Castellanos FX, Rajapakse JC. Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry. 1997;21:1185–1201
  37. Goy RW, McEwen BS. Sexual Differentiation of the Brain (Based on a work session of the neuroscience research program). Cambridge, MA: MIT Press; 1980;
  38. Carroll BJ, Curtis GC, Mendels J. Neuroendocrine regulation in depression. I. Limbic system—adrenocortical dysfunction. Arch Gen Psychiatry. 1976;33:1039–1044
  39. Sachar EJ, Halpern F, Rosenfeld RS, et al.  Plasma and urinary testosterone levels in depressed men. Arch Gen Psychiatry. 1973;28:15–80
  40. Jones MT, Brush FR, Neame RL. Characteristics of fast feedback control of corticotrophin release by corticosteroids. J Endocrinol. 1972;55:489–497
  41. Young EA. Sex differences in response to exogenous corticosterone (A rat model of hypercortisolemia). Mol Psychiatry. 1996;1:313–319
  42. Burgess LH, Handa RJ. Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats. Endocrinology. 1992;131:1261–1269
  43. Viau V, Meaney MJ. Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat. Endocrinology. 1991;129:2503–2511
  44. Keller-Wood M, Silbiger J, Wood CE. Progesterone attenuates the inhibition of adrenocorticotropin responses by cortisol in nonpregnant ewes. Endocrinology. 1988;123:647–651
  45. Vamvakopoulos NC, Chrousos GP. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimorphism of the stress response and immune/inflammatory reaction. J Clin Invest. 1993;92:1896–1902
  46. Turner BB, Weaver DA. Sexual dimorphism of glucocorticoid binding in rat brain. Brain Res. 1985;343:16–23
  47. Kirschbaum C, Schommer N, Federenko I, et al.  Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psychosocial stress in healthy young men. J Clin Endocrinol Metab. 1996;81:3639–3643
  48. Altemus M, Redwine L, Leong YM, et al.  Reduced sensitivity to glucocorticoid feedback and reduced glucocorticoid receptor mRNA expression in the luteal phase of the menstrual cycle. Neuropsychopharmacology. 1997;17:100–109
  49. Young EA, Haskett RF, Murphy-Weinberg V, et al.  Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry. 1991;48:693–699
  50. Young EA, Haskett RF, Grunhaus L, et al.  Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients. Arch Gen Psychiatry. 1994;51:701–707
  51. Young EA, Kotun J, Haskett RF, et al.  Dissociation between pituitary and adrenal suppression to dexamethasone in depression. Arch Gen Psychiatry. 1993;50:395–403
  52. Mitsushima D, Hei DL, Terasawa E. Gamma-aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA. 1994;91:395–399
  53. Terasawa E, Luchansky LL, Kasuya E, Nyberg CL. An increase in glutamate release follows a decrease in gamma aminobutyric acid and the pubertal increase in luteinizing hormone releasing hormone release in the female rhesus monkeys. J Neuroendocrinol. 1999;11:275–282
  54. Terasawa E, Fernandez DL. Neurobiological mechanisms of the onset of puberty in primates. Endocr Rev. 2001;22:111–151
  55. Genazzani AR, Bernardi F, Monteleone P, et al.  Neuropeptides, neurotransmitters, neurosteroids, and the onset of puberty. Ann N Y Acad Sci. 2000;900:1–9
  56. Grumbach MM, Styne DM. Puberty, ontogeny, neuroendocrinology, physiology, and disorders. In:  Wilson JD,  Foster DW,  Kronenberg HM,  Larsen PR editor. Williams Textbook of Endocrinology. 9th edition.. Philadelphia: W.B. Saunders Company; 1998;p. 1509–1625
  57. Sanborn K, Hayward C. Hormonal changes at puberty and the emergence of gender differences in internalizing disorders. In: Hayward C (ed). Gender Differences at Puberty. Cambridge University Press, London. (In press)
  58. Parker S, Nichter M, Nichter M, et al.  Body image and weight concerns among African-American and White adolescent females (Differences that make a difference). Human Organization. 1995;54:103–114
  59. Casper R, Offer D. Weight and dieting concerns in adolescents, fashion or symptom?. Pediatrics. 1990;86:384–390
  60. Dolan BM, Lacey JH, Evans C. Eating behaviour and attitudes to weight and shape in British women from three ethnic groups. Br J Psychiatry. 1990;157:523–528
  61. Felts WM, Parrillo AV, Chenier T, Dunn P. Adolescents perceptions of relative weight and self-reported weight-loss activities (Analysis of 1990 YRBS national data). J Adolescent Health. 1996;18:20–26
  62. Rucker CE, Cahs TF. Body images, body-size perceptions, and eating behaviors among African-American and White college women. Int J Eat Disord. 1992;12:291–299
  63. Hayward C, Gotlib IH, Schraedley PK, Litt IF. Ethnic differences in the association between pubertal status and symptoms of depression in adolescent girls. J Adolesc Health. 1999;25:143–149
  64. Cutler SE, Nolen-Hoeksema S. Accounting for sex differences in depression through female victimization (Childhood sexual abuse). Sex Roles. 1991;24:425–438
  65. MacMillan HL, Fleming JE, Trocme N, et al.  Prevalence of child physical and sexual abuse in the community (Results from the Ontario Health Supplement). JAMA. 1997;277:131–135
  66. Olsen LJ, Holmes WM. Youth at risk (Adolescents and maltreatment). Child Youth Serv Rev. 1986;8:13–35
  67. Rosenthal JA. Patterns of reported child abuse and neglect. Child Abuse Negl. 1988;12:263–271
  68. Boney-McCoy S, Finkelhor D. Is youth victimization related to trauma symptoms and depression after controlling for prior symptoms and family relationships? A longitudinal, prospective study. J Consult Clin Psychol. 1996;64:1406–1416
  69. Poitras M, Lavoie F. A study of the prevalence of sexual coercion in adolescent heterosexual dating relationships in a Quebec sample. Violence Vict. 1995;10:299–313
  70. Crick NR, Bigbee MA. Relational and overt forms of peer victimization (A multiinformant approach). J Consult Clin Psychol. 1998;66:337–347
  71. Gidycz CA, Hanson K, Layman MJ. A prospective analysis of the relationships among sexual assault experiences (An extension of previous findings). Psychol Women Quart. 1995;19:5–29
  72. Silverman AB, Reinherz HZ, Giaconia RM. The long-term sequelae of child and adolescent abuse (A longitudinal community study). Child Abuse Negl. 1996;20:709–723
  73. Feiring C, Taska L, Lewis M. Age and gender differences in children’s and adolescents adaptation to sexual abuse. Child Abuse Negl. 1999;23:115–128
  74. Weiss EL, Longhurst JG, Mazure CM. Childhood sexual abuse as a risk factor for depression in women (Psychosocial and neurobiological correlates). Am J Psychiatry. 1999;156:816–828
  75. Meaney MJ, Diorio J, Francis D, et al.  Early environmental regulation of forebrain glucocorticoid receptor gene expression (implications for adrenocortical responses to stress). Dev Neurosci. 1996;181:49–72
  76. Cauffman E, Steinberg L. Interactive effects of menarcheal status and dating on dieting and disordered eating among adolescent girls. Dev Psychol. 1996;32:631–635
  77. Gralen SJ, Levine MP, Smolak L, Munren SK. Dieting and disordered eating during early and middle adolescence (Do the influences remain the same?). Int J Eat Disord. 1990;9:501–512
  78. Levine MP, Smolak L, Hayden H. The relation of sociocultural factors to eating attitudes and behaviors among middle school girls. J Early Adolesc. 1994;14:471–490
  79. Pawlby SJ, Mills A, Quinton D. Vulnerable adolescent girls (Opposite-sex relationships). J Child Psychol Psyc. 1997;38:909–920
  80. In:  Mrazek PJ,  Haggerty RJ editor. Reducing Risks for Mental Disorders (Committee on Prevention of Mental Disorders). Washington, DC: Institute of Medicine, National Academy Press; 1994;
  81. Rutter M, Garmezy N. Developmental psychopathology. In:  Hetherington EM editors. Socialization, personality, and social development, Vol. 4. Mussen’s Handbook of Child Psychology. 4th Edition.. New York: Wiley & Sons; 1983;p. 775–911
  82. Sroufe LA, Rutter M. The domain of developmental psychopathology. Child Dev. 1984;55:17–29
  83. Cicchetti D. Developmental psychopathology (Past, present and future). In:  Cicchetti D editors. The Emergence of a Discipline (The Rochester Symposium on Developmental Psychopathology). Vol. 1:Hillsdale, NJ: Lawrence Erlbaum Associates; 1989;p. 1–12

PII: S1054-139X(02)00336-1

Journal of Adolescent Health
Volume 30, Issue 4, Supplement 1 , Pages 49-58 , April 2002